I frequently mentioned Chris Carpenter's excellent 2011 systematic review of ED septic arthritis; Margaretten's Systematic Review for JAMA is also worth a look.
Other references from my talk:
- Terkeltaub's trial that changed colchicine regimens for gout
- Kesselheim and Solomon in NEJM 2010 on the Curious Case of Colchicine
- Piper on the risks of local anesthetics on cartilage
- Fitch 2008 on IA lidocaine for shoulder reduction in the ED
I think I'll borrow a page from the Newman playbook and recommend shared decision-making with the patient - "while no studies have shown this dose or a one-time exposure in humans is dangerous, and the majority of patients who get pump infusions have no detectable adverse reaction years later, there is a risk and the benefit is just a few hours of relief, sooner"